
Paula's Choice
Paula's Choice Clinical 1% Retinol Treatment
4.8· Best for: Experienced retinol users targeting deeper wrinkles.
A 1% retinol concentrate paired with peptides, vitamin C and licorice extract to visibly smooth deep wrinkles and even tone.
Check best priceAffiliate link · price set by retailer
Pros
- +Strong 1% retinol
- +Stable airless pump
- +Includes brightening actives
Cons
- —Too strong for first-time retinol users
- —Mild dryness possible
Key features
- 1% stabilized retinol
- Peptides + vitamin C
- Licorice and oat extracts
- Fragrance-free
Scientific Evidence
Topical retinol at 0.5–1% has substantial evidence for increasing dermal collagen and reducing wrinkle depth over 12–24 weeks of nightly use.
Frequently asked
How often should I use it?+
Start 2 nights per week and gradually build to nightly as tolerated.
Pair with what SPF?+
Any broad-spectrum SPF 30+ daily is essential while using retinol.
Ready to try Paula's Choice?
High-strength encapsulated retinol with peptides and antioxidants.

